DemircanLab

* Turan Demircan’ın sorumlu ya da eş-sorumlu yazar olduğu yayınlar

2026

Kahyaogullari, B. N., & Demircan, T*. (2026). Computational dissection of m5C/hm5C regulators in prostate adenocarcinoma reveals UHRF1, NSUN2, and NEIL1 as biomarkers associated with pathogenesis. Biomed Eng Commun, 5(3), 15.

2025

Açcan, G., Demircan, T*. (2025). Dysregulation of m6A, m5C, and m1A Pathways in Gliomas Reveals EIF3A and TET1 as Candidate Biomarkers. Eurasian Mol Biochem Sci 2025;4(2):99-115

Rohmatika, A. U., Demircan, T., Jamil, A. K. M., & Dewi, F. R. P. (2025). Exploring 5, 7-dimethoxyflavone from Piper ornatum as a novel anti-breast cancer candidate: insights from in silico analysis. Brazilian journal of biology= Revista brasleira de biologia, 85, e288642.

Demircan, T*., Milinkovic, D., Çetin, E.S., Aksu, E., Tagit, O. (2025). Harnessing Nanoencapsulation for the Repurposing of Hydroquinidine Against Breast Cancer. Journal of Drug Delivery Science and Technology, 110, 107098

Göktürk, T., Demircan, T*, Hökelek, T., Yavuz, M., Güp, R., Topkaya, C. (2025). Crystal Structure Analysis and Anticancer Potential of a Naphthalene-Based Schiff Base Against Breast Cancer. Acta Chim. Slov.2025,72, 299–308

Dewi, F. R., Rohmatika, A. U., Jamil, A. K., Demircan, T., Idris, M. F., Litazkiyyah, L., … & Sugiharto, S. (2025). Plant-based synthesis of gold and silver nanoparticles using Artocarpus heterophyllus aqueous leaf extract and its anticancer activities. Narra J, 5(2), e1770-e1770.

Yavuz, M., Kahyaogullari, B., & Demircan, T*. (2025). Anti-carcinogenic effects of arecaidine but-2-ynyl ester tosylate on breast cancer: proliferation inhibition and activation of apoptosis. Molecular Biology Reports, 52(278).

Demircan, T*., Yavuz, M., & Bölük, A. (2025). Unveiling the Potential of S4 on Non-small Cell Lung Cancer Cells: Impact on Proliferation, Apoptosis, Senescence, and Metabolome Profile. Anti-cancer agents in medicinal chemistry.

Bircan, H., Demircan, T., Yulek, F., & Yuksel, N. (2025). PCR-based characterization of nasal and ocular surface flora and functional analysis of bacterial metabolic pathways in congenital nasolacrimal duct obstruction. International Ophthalmology, 45(1), 1-8.

Sakinah, J., Rohmatika, A. U., Lim, V., Demircan, T., & Dewi, F. R. P. (2025). Discovering the potential of bioactive compounds from curcuma aeruginosa as anti-ovarian cancer agent through in silico approach targeting TNFα. Journal of Medicinal and Pharmaceutical Chemistry Research, 7(8), 1730-1746.

Göktürk, T., Topkaya, C., Demircan, T*., Akgül, S., Hökelek, T., & Güp, R. (2025). Novel benzohydrazide derivative as a potential anticarcinogenic agent for breast cancer: Synthesis, crystal structure, in vitro and in silico assessments. Journal of Molecular Structure, 1323, 140673.

2024

Bulbul, M. V., Mermer, A., Kolbasi, B., Kocabas, F., Kalender, S. M., Kirectepe Aydin, K. A., … Demircan, T., & Keskin, İ. (2024). mTOR Pathway Inhibition, Anticancer Activity and In Silico Calculations of Novel Hydrazone Derivatives in Two-and Three-Dimensional Cultured Type 1 Endometrial Cancer Cells. Pharmaceuticals, 17(12), 1562.

Altın, H., Delice, B., Yıldırım, B., Demircan, T., & Yıldırım, S. (2024). Temporal microbiome changes in axolotl limb regeneration: Stage‐specific restructuring of bacterial and fungal communities with a Flavobacterium bloom during blastema proliferation. Wound Repair and Regeneration, 32(6), 826-839.

Yavuz, M., & Demircan, T*. (2024). Exploring the Potentials of S4, A Selective Androgen Receptor Modulator, in Glioblastoma Multiforme Therapy. Toxicology and Applied Pharmacology 490, 117029

Demircan, T*., Gül, S., & Taşçı, E. A. (2024). Can Microbiome Modulate Regenerative Capacity? A Comparative Microbiome Study Reveals a Dominant Presence of Flavobacteriaceae in Blastema Tissue During Axolotl Limb Regeneration. OMICS: A Journal of Integrative Biology. 28 (6), 291-302

Yavuz, M., & Demircan, T*. (2024). Hydroquinidine Demonstrates Remarkable Antineoplastic Effects on Non-small Cell Lung Cancer Cells. Current Molecular Medicine, 24(9), 1159-1168.

2023

Demircan, T*., & Süzek, B. E. (2023). The Dynamic Landscapes of Circular RNAs in Axolotl, a Regenerative Medicine Model, with Implications for Early Phase of Limb Regeneration. OMICS: A Journal of Integrative Biology, 27(11), 526-535.

Bölük, A., Yavuz, M., Takanlou, M. S., Avcı, Ç. B., & Demircan, T*. (2023). In vitro anti-carcinogenic effect of andarine as a selective androgen receptor modulator on MIA-PaCa-2 cells by decreased proliferation and cell-cycle arrest at G0/G1 phase. Biochemical and Biophysical Research Communications, 671, 132-139.

Bay, S., Öztürk, G., Emekli, N., & Demircan, T*. (2023). Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl. Developmental Biology, 500, 31-39.

Yavuz, M., Takanlou, L. S., Avcı, Ç. B., & Demircan, T*. (2023). A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling pathway. Gene, 869, 147390.

Barcın‐Güzeldere, H. K., Aksoy, M., Demircan, T., Yavuz, M., & Beler, M. (2023). Association between the anthropometric measurements and dietary habits on telomere shortening in healthy older adults: A‐cross‐sectional study. Geriatrics & Gerontology International, 23(7), 565-572.

Yavuz, M., & Demircan, T*. (2023). A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Molecular Biology Reports, 50(3), 2611-2621.

Yavuz, M., Şahin, B., Baykal, A. T., & Demircan, T*. (2023). Hydroquinidine displays a significant anti-carcinogenic activity in breast and ovarian cancer cells via inhibiting cell-cycle and stimulating apoptosis. Turkish Journal of Biology, 47(1), 44-60.

Yavuz, M., & Demircan, T*. (2023). The effect of hydroquinidine on proliferation and apoptosis of TMZ-sensitive and-resistant GBM Cells. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 23(8), 938-952.

2022

Bölük, A., Yavuz, M., & Demircan, T*. (2022). Axolotl: A resourceful vertebrate model for regeneration and beyond. Developmental Dynamics, 251(12), 1914-1933.

Gumus, E., Temiz, E., Demircan, T., Sarikaya, B., Yuksekdag, O., Bozkurt, C., … & Oz, O. (2022). The Link between miR-96 Levels and the Developmental Dysplasia of the Hip. Gazi Medical Journal, 33(3).

Yavuz, M., Akgul, S., Kaya, E., & Demircan, T.* (2022). Conditioned Medium of Glioblastoma Cells Decreases the Viability of Each Other by Modulating Apoptosis-and Proliferation-Related Gene Expression. Jentashapir Journal of Cellular and Molecular Biology, 13(2).

2021

Demircan, T*., Yavuz, M., & Akgül, S. (2021). m6A pathway regulators are frequently mutated in breast invasive carcinoma and may play an important role in disease pathogenesis. OMICS: A Journal of Integrative Biology, 25(10), 660-678.

Demircan, T.*, Yavuz, M., Kaya, E., Akgül, S., & Altuntaş, E. (2021). Cellular and molecular comparison of glioblastoma multiform cell lines. Cureus, 13(6).

Demircan, T*., Sibai, M., Avşaroğlu, M. E., Altuntaş, E., & Ovezmyradov, G. (2021). The first report on circulating microRNAs at Pre-and Post-metamorphic stages of axolotls. Gene, 768, 145258.

2020

Sibai, M., Altuntaş, E., Yıldırım, B., Öztürk, G., Yıldırım, S., & Demircan, T*. (2020). Microbiome and longevity: high abundance of longevity-linked muribaculaceae in the gut of the long-living rodent spalax leucodon. OMICS: A Journal of Integrative Biology, 24(10), 592-601.

Demircan, T*., Sibai, M., & Altuntaş, E. (2020). Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages. Data in brief, 29, 105179.

Sibai, M., Altuntaş, E., Süzek, B. E., Şahin, B., Parlayan, C., Öztürk, G., … & Demircan, T*. (2020). Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl. Biochemical and biophysical research communications, 522(2), 428-434.

Demircan, T*. (2020). Dissecting the molecular signature of spinal cord regeneration in the axolotl model. Cureus, 12(2).

Demircan, T*., Hacıbektaşoğlu, H., Sibai, M., Fesçioğlu, E. C., Altuntaş, E., Öztürk, G., & Süzek, B. E. (2020). Preclinical molecular signatures of spinal cord functional restoration: Optimizing the metamorphic axolotl (Ambystoma mexicanum) model in regenerative medicine. OMICS: A Journal of Integrative Biology, 24(6), 370-378.

2019

Sibai, M., Parlayan, C., Tuğlu, P., Öztürk, G., & Demircan, T*. (2019). Integrative analysis of axolotl gene expression data from regenerative and wound healing limb tissues. Scientific Reports, 9(1), 20280.

Demircan, T*., İlhan, A. E., Ovezmyradov, G., Öztürk, G., & Yıldırım, S. (2019). Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl Ambystoma mexicanum. Scientific data, 6(1), 70.

2018

Demircan, T*., Ovezmyradov, G., Yıldırım, B., Keskin, I., Ilhan, A. E., Fesçioglu, E. C., … & Yıldırım, S. (2018). Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota, Sci. Rep. 8 (2018) 10974.

Jantsch, M. F., Quattrone, A., O’Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., … & Fray, R. (2018). Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA biology, 15(6), 829-831.

2017

Wudarski, J., Simanov, D., Ustyantsev, K., De Mulder, K., Grelling, M., Grudniewska, M.,Demircan, T, … & Berezikov, E. (2017). Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano. Nature communications, 8(1), 2120.

Demircan, T*., Avşaroğlu, M. E., Öztürk, G., & Keskin, İ. (2017). Aksolotl Rejenerasyonunun Farklı Evrelerinde miRNA Profilinin Bulunması ve Bulunan miRNA’ların Görevlerinin In-siliko Analizi. Haydarpasa Numune Med J, 57(3), 125-134

Keskin, I., Yıldırım, B., KOLBAŞI, B., Öztürk, G., & Demircan, T. (2017). A comparative study of fixatives for axolotl blastema tissue Estudio Comparativo de Fijadores para el Tejido Blastema del Axolotl. International Journal of Morphology, 35(1).

Demircan, T., Keskin, I., Dumlu, S. N., Aytürk, N., Avşaroğlu, M. E., Akgün, E., … & Baykal, A. T. (2017). Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA‐seq reference database. Proteomics, 17(1-2), 1600338.

2016

Demircan, T*., Keskın, İ., Gunal, Y., Ilhan, A. E., Kolbası, B., & Ozturk, G. (2016). Axolotl cells and tissues enhances cutaneous wound healing in mice. Journal of Experimental and Clinical Medicine, 33(4).

Demircan, T*., İlhan, A. E., Aytürk, N., Yıldırım, B., Öztürk, G., & Keskin, İ. (2016). A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl. Acta histochemica, 118(7), 746-759.

2013

Schwank, G., Koo, B. K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., … & Clevers, H. (2013). Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell stem cell, 13(6), 653-658.

Demircan, T., & Berezikov, E. (2013). The Hippo pathway regulates stem cells during homeostasis and regeneration of the flatworm Macrostomum lignano. Stem Cells and Development, 22(15), 2174-2185.

2010

Demircan, T., & Akkaya, M. S. (2010). Virus induced gene silencing in Brachypodium distachyon, a model organism for cereals. Plant Cell, Tissue and Organ Culture (PCTOC), 100, 91-96.